PubMed abstract (March 2001): Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations. Background: In population studies, high intakes of coffee are associated with raised concentrations of plasma homocysteine, a predictor of risk of cardiovascular disease. Chlorogenic acid is a major polyphenol in coffee; coffee drinkers consume up to 1 g chlorogenic acid/d. ⟵ Full text link ⟿ http://ajcn.nutrition.org/content/73/3/532.long