The association between omega-3 supplementation and cognitive decline in older adults https://www.sciencedirect.com/science/article/pii/S2274580726000932 These findings challenge the prevailing view of omega-3 as uniformly beneficial and highlight the need for a cautious reassessment of its use for cognitive protection A systematic review in 2025 found that low-dose omega-3 supplements are associated with benefits for cognition, but that high doses above 1500 mg a day may reverse that advantage in some ppl https://www.sciencealert.com/omega-3-supplements-may-increase-risk-of-cognitive-decline-scientists-warn While Ω3 fatty acid supplementation is widely used for cognitive protection, its efficacy, its dosage and composition (EPA and DHA) remain controversial, and its impact on core Alzheimer's disease (AD) pathologies in humans is not well-established.