Cheap supplement CREATINE protected the brain from gut inflammation in rats with chronic colitis https://www.sciencedirect.com/science/article/pii/S088915912600677X It blocked brain inflammation, neuron loss and faulty electrical signals in the brain's memory center hippocampus. It's not yet tested in humans https://medicalxpress.com/news/2026-10-popular-sports-supplement-shield-brain.html in rats with colitis, creatine improved several markers of healthy brain activity. The supplementation restored hippocampal creatine levels, preserved neuronal integrity, and normalized impaired excitability. The research team found that the benefits of creatine for male rats with colitis were more apparent than for females. This is probably because in males, the brain damage associated with colitis seems to be worse than in the opposite sex. The findings suggest that some inflammatory conditions may impact the male and female brain differently, and that creatine supplementation may help prevent some of these ramifications https://www.sciencealert.com/creatine-could-protect-the-brain-from-gut-inflammation