Mitochondrial dysfunction is a driver of the different types of renal lithiasis. L-Ergothioneine solves it fully: the molecule is transported directly to the kidney and reverses the oxidative stress that may exist, restoring the functioning of the mitochondria https://medicalxpress.com/news/2026-04-therapeutic-potential-natural-antioxidant-kidney.html L-Ergothioneine Attenuates Nephrolithiasis by Modulating Redox Signaling and Mitochondrial Function in Cystine and Calcium Oxalate Models https://journals.sagepub.com/doi/10.1177/15230864261431276 L-ergothioneine, a naturally occurring antioxidant transported by OCTN1, has shown promising effects in cystinuria models, preventing stone formation. Ergothioneine (EGT) is a naturally occurring, sulfur-containing amino acid that is increasingly being researched as a potential longevity substance due to its pronounced cell-protective properties https://www.youtube.com/watch?v=A6emxvltekk