A study has shown that both caffeinated and decaffeinated black coffee (without milk, sugar, sweetener) may be helpful in inducing autophagy, specifically in the heart and muscle. Coffee can help mimic caloric restriction, which may be one of the reasons it can be helpful in triggering autophagy https://spermidinelife.us/blogs/news/does-coffee-help-trigger-autophagy While triggering autophagy is a wonderful way to help the body detoxify, supplements like spermidine may be helpful as well. Spermidine helps counteract aging and promotes autophagy. As the body ages, the levels of spermidine naturally fall