High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial https://jamanetwork.com/journals/jama/article-abstract/2831270 Clinical trial: High‑dose vitamin D significantly reduces disease activity in early multiple sclerosis onset https://medicalxpress.com/news/2025-03-highdose-vitamin-d-significantly-disease.html Conclusions: Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitting MS. These results warrant further investigation, including the potential role of pulse high-dose vitamin D as add-on therapy