Magnesium transport across the blood-brain barriers https://www.ncbi.nlm.nih.gov/books/NBK507259/ The BBB plays a pivotal role in the tight regulation and rigorous stabilization of the chemical composition of brain ECF, thus promoting normal neuronal signaling https://www.verywellhealth.com/magnesium-l-threonate-8732187 Unlike other supplemental forms of magnesium, magnesium L-threonate can cross the blood-brain barrier, offering a slew of cognitive benefits. Although research is limited, studies thus far show a potential benefit of magnesium L-threonate for anxiety and stress, ADHD, sleep, and cognitive function