Age-related GABA decline is associated with poor cognition https://medicalxpress.com/news/2017-01-age-related-gaba-decline-poor-cognition.html Cognitive function is sensitive to cerebral GABA concentrations in the frontal cortex. GABA concentration in frontal and posterior regions continue to decline in later age https://sciencedirect.com/science/article/abs/pii/S2451902216300696