Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1 Alzheimer's disease can be reversed in animal models to achieve full neurological recovery https://medicalxpress.com/news/2025-12-alzheimer-disease-reversed-animal-full.html Dr. Pieper emphasized that currently available over-the-counter NAD+ precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer. The approach in this study, however, uses a pharmacological agent (P7C3-A20) that enables cells to maintain their proper balance of NAD+ under conditions of otherwise overwhelming stress, without elevating NAD+ to supraphysiologic levels