Sugar Substitute Xylitol Could Have Some Major Heart-Health Risks https://time.com/6985904/xylitol-heart-health-risks/ Xylitol (found even toothpaste) is associated with incident MACE risk. Xylitol both enhanced platelet reactivity and thrombosis potential in vivo https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehae244/7683453 Further studies are warranted!