Gut microbe molecule reveals molecular link between microbiome and whole-body metabolism https://medicalxpress.com/news/2026-09-gut-microbe-molecule-reveals-molecular.html Microbiome-host communication via vaccenic acid modulates LRH-1/NR5A2 activity and ameliorates metabolic liver disease. https://link.springer.com/article/10.1038/s44321-026-00516-3 Interactions between microbiota and the host can profoundly affect human health. In particular, microbiota-derived metabolites influence liver physiology and contribute to the development of metabolic diseases, yet the molecular mechanisms underlying microbiome-host communication remain incompletely understood.