A decade-long study by Harvard Medical School scientists suggests that a deficiency of naturally occurring lithium in the brain could be a key factor in the development of Alzheimer's disease: Lithium deficiency and the onset of Alzheimer’s disease https://www.nature.com/articles/s41586-025-09335-x Endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing https://www.independent.co.uk/bulletin/news/dementia-alzheimers-disease-cause-deficiency-b2803824.html Scientists discovered that lithium orotate can bypass amyloid plaques and effectively restore memory in mice at a significantly lower dose than traditional lithium treatments. "Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment". Lithium deficiency accelerates AD pathology and cognitive decline. “A mouse is not a human. Nobody should take anything based just on mouse studies”. “The lithium treatment data we have is in mice, and it needs to be replicated in humans. We need to find the right dose in humans” https://edition.cnn.com/2025/08/06/health/lithium-alzheimers-brain-study