The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure (2014) https://www.sciencedirect.com/science/article/pii/S2213177914003369 Patients with moderate to severe HF were randomly assigned in a 2-year prospective trial to either CoQ10 100 mg 3 times daily or placebo, in addition to standard therapy https://youtu.be/XuU6rBlfYnU?t=2410 Long-term CoQ10 treatment of patients with chronic HF is safe, improves symptoms, and reduces major adverse cardiovascular events.